SYSTEMIC THROMBOLYTIC THERAPY IN ACUTE MY OCARDIAL-INFARCTION - EFFECT ON LEFT-VENTRICULAR FUNCTION, OXYGEN SYSTEMIC SUPPLY AND OUTCOME OF THE DISEASE

Echocardiography, integral rheography of the body, Holter monitoring, assessment of oxygen consumption and blood gases were used in examinat ion of 93 patients with macrofocal myocardial infarction (MI). 48 pati ents received thrombolytic therapy (TT) within 6 hours of MI which in 27 patients implied standard drugs (streptodecase, celiase, avelysin) and new medicine APSAC (21 patients). 45 patients received no TT. It w as found that in acute MI period systemic TT prevented a fall in left ventricular performance, promoted advanced oxygen supply due to intens ified oxygen extraction by tissues. This fact is attributed to transie nt changes in blood rheology. Application of APSAC prevented inhibitio n of myocardial contractility and development of congestive heart fail ure in subacute MI period. TT patients demonstrated ventricular arrhyt hmia on MI day 1 more often though the number of the main arrhythmia t ypes the groups differed insignificantly. Within 1-year postmyocardial infarction period TT patients had less repeat MI and were less freque ntly diagnosed to develop congestive heart failure.