FRAXIPARIN ACTION ON PLATELET-VASCULAR HE MOSTASIS IN PATIENTS WITH UNSTABLE ANGINA-PECTORIS

Clinical examination of 25 males with new-onset and progressive angina pectoris resistant to inpatient combined antianginal treatment versus 15 healthy males established hyperfunction of the platelets in low an tithrombogenic activity of the vascular walls in patients with unstabl e angina pectoris. A 5-day course of fraxiparin resulted in a trend to a decrease in ADP-induced platelet aggregation and in the level of pl atelet factor IV. The endothelium recovered normal antiaggregation and fibrinolytic properties. This may underlie the drug efficacy against unstable angina pectoris.