IMMUNE STATUS IN VARIOUS CLINICAL-VARIETI ES OF INSULIN-DEPENDENT DIABETES-MELLITUS

Immune status with reference to the disease duration and genetic facto rs (HLA-typing) was studied in various clinical variants of insulin-de pendent diabetes mellitus. The disease duration appeared the key facto r in development of immune deficiency in insulin-dependent diabetes me llitus. Critical immunological values were established (CD5+ cells - 1 200 in 1 mul, CD4+ cells - 35 %, expression of CD5 and antigens HLA cl ass II - 110 and 75 %, respectively) for septic complications which ar e highly probable in lower indices. Females with diffuse thyroid enlar gement subclinical hypothyroidism, wide spectrum of antibodies to DNA, antigenic determinants of thyroid gland, hypophysis were found to be a group associated with HLA - DR3 carriage.