CLINICOPATHOGENIC ASPECTS OF SEXUAL DIMOR PHISM IN GOUT

Authors
SINYACHENKO OV KOSHELEVA YN MUKHIN IV SINYACHENKO TY TKACHENKO LI TOLSTOY VA
Citation
Ov. Sinyachenko et al., CLINICOPATHOGENIC ASPECTS OF SEXUAL DIMOR PHISM IN GOUT, Terapevticeskij arhiv, 65(10), 1993, pp. 46-50
Citations number
8
Categorie Soggetti
Medicine, General & Internal
Journal title
Terapevticeskij arhiv → ACNP
ISSN journal
00403660
Volume
65
Issue
10
Year of publication
1993
Pages
46 - 50
Database
ISI
SICI code
0040-3660(1993)65:10<46:CAOSDP>2.0.ZU;2-X
Abstract
The examination of 241 gout patients (207 males and 34 females) reveal ed a marked sexual dimorphism of the disease related to the articular and renal syndromes. Male gout is characterized by higher blood levels of uric acid and oxypurinole in reduced clearance of the latter, whil e in female gout there were hyperxanthinoxidasemia and hypo-cAMPemia. Unbalance of sex and gonadotropic hormones, which appeared multidirect ional and dependent on the sex, was observed in males in the form of l ower concentrations of blood testosterone and estradiol against elevat ed levels of progesteron and lutropin, in females manifested with hypo progesteronemia and reduced gonadotropin.