OXIME ANALOGS OF AMINO-ACIDS AND PEPTIDES ARE EFFICIENT LIGANDS FOR NI-II IONS

Oxime derivatives of amino acids, amides, and peptides are very effici ent ligands for Ni-II ions forming very stable water-soluble complexes . Oxime of amino acids amides forms octahedral and square-planar compl exes with the same 4N coordination mode. The spectroscopic and X-ray d iffraction studies indicate an unusual role for the hydrogen bond in N iH(-1)L(2) species, which stabilizes the cis coordination of two ligan ds in a planar complex. Oxime analogs of natural amino acid can be muc h more efficient ligands than the parent molecules. (C) 1997 Elsevier Science Inc.