GENETIC-MAPPING OF 21 GENES ON MOUSE CHROMOSOME-11 REVEALS DISRUPTIONS IN LINKAGE CONSERVATION WITH HUMAN-CHROMOSOME-5

We report a high-resolution genetic map of 21 genes on the central reg ion of mouse Chr 11. These genes were mapped by segregation analysis o f more than 1650 meioses from three interspecific backcrosses. The ord er of these genes in mouse was compared to the previously established gene order in human. Eighteen of the 21 genes map to human Chr 5, and 2 of the genes define a proximal border for the region of homology bet ween mouse Chr 11 and human Chr 17. Our results indicate a minimum of four rearrangements within the 10-cM region of synteny homology betwee n mouse Chr 11 and human Chr 5. In addition, the linkage conservation is disrupted by groups of genes that map to mouse Chrs 13 and 18. Thes e data demonstrate that large regions of conserved linkage can contain numerous chromosomal microrearrangements that have occurred since the divergence of mouse and human ancestors. Comparison of the mouse and human maps with data for other species provides an emerging picture of mammalian chromosome evolution. (C) 1997 Academic Press.