GENETIC POLYMORPHISMS IN HLA-A, HLA-B, HLA-C AND HLA-DR ANTIGENS IN JAPANESE PATIENTS WITH PALMOPLANTAR PUSTULOSIS

Authors
TORII H NAKAGAWA H ISHIBASHI Y TOKUNAGA K JUJI T
Citation
H. Torii et al., GENETIC POLYMORPHISMS IN HLA-A, HLA-B, HLA-C AND HLA-DR ANTIGENS IN JAPANESE PATIENTS WITH PALMOPLANTAR PUSTULOSIS, Dermatology, 188(4), 1994, pp. 290-292
Citations number
14
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
Dermatology → ACNP
ISSN journal
10188665
Volume
188
Issue
4
Year of publication
1994
Pages
290 - 292
Database
ISI
SICI code
1018-8665(1994)188:4<290:GPIHHH>2.0.ZU;2-2
Abstract
Genetic polymorphisms in HLA-A, -B, -C and -DR antigens were investiga ted in 78 unrelated Japanese patients with palmoplantar pustulosis (PP P) and compared with a total of 472 normal persons. Only HLA-DR9 showe d a significantly increased frequency among all HLA antigens investiga ted (chi(2)=11.57, p<0.001). It is suggested that major histocompatibi lity complex class II antigens including HLA-DR antigen may determine the susceptibility to PPP and PPP may be a distinct disease entity fro m psoriasis.