EXTRACTION PROCEDURES FOR THE HPLC DETERMINATION OF 5-FLUOROURACIL INBIOLOGICAL SAMPLES

Authors
DELNOZAL MJ BERNAL JL MARINERO P PAMPLIEGA A
Citation
Mj. Delnozal et al., EXTRACTION PROCEDURES FOR THE HPLC DETERMINATION OF 5-FLUOROURACIL INBIOLOGICAL SAMPLES, Journal of liquid chromatography, 17(7), 1994, pp. 1621-1636
Citations number
12
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of liquid chromatography → ACNP
ISSN journal
01483919
Volume
17
Issue
7
Year of publication
1994
Pages
1621 - 1636
Database
ISI
SICI code
0148-3919(1994)17:7<1621:EPFTHD>2.0.ZU;2-5
Abstract
An extraction procedure was optimized for the reversed-phase high perf ormance liquid chromatographic determination of 5-Fluorouracil in rabb it plasma, liver, kidney, lung and heart samples. The extraction condi tions are adapted to each type of matrix in order to achieve high extr action yields (ca 90%) and interference-free chromatographic peaks.