IDIOPATHIC RECURRING STUPOR

Citation
P. Tinuper et al., IDIOPATHIC RECURRING STUPOR, Neurology, 44(4), 1994, pp. 621-625
Citations number
35
Categorie Soggetti
Clinical Neurology
Journal title
ISSN journal
00283878
Volume
44
Issue
4
Year of publication
1994
Pages
621 - 625
Database
ISI
SICI code
0028-3878(1994)44:4<621:IRS>2.0.ZU;2-Q
Abstract
Idiopathic recurring stupor (IRS) is a disease of unknown pathogenesis presenting with recurrent stuporous states. We describe three IRS pat ients in whom there were no metabolic, toxic, or structural brain dysf unctions. Ictal EEGs were characterized by fast (14- to 16-Hz), unreac tive background activity. Flumazenil, a benzodiazepine receptor antago nist, promptly resolved the clinical and EEG picture. In all patients, ictal plasma determination showed a marked increase in benzodiazepine -like activity identified as endozepine-4. IRS may be due to an unexpl ained excess of endozepine-4.