REIDISPONGIOLIDE-A AND REIDISPONGIOLIDE-B, 2 NEW POTENT CYTOTOXIC MACROLIDES FROM THE NEW-CALEDONIAN SPONGE REIDISPONGIA-COERULEA

Authors
DAURIA MV PALOMA LG MINALE L ZAMPELLA A VERBIST JF ROUSSAKIS C DEBITUS C PATISSOU J
Citation
Mv. Dauria et al., REIDISPONGIOLIDE-A AND REIDISPONGIOLIDE-B, 2 NEW POTENT CYTOTOXIC MACROLIDES FROM THE NEW-CALEDONIAN SPONGE REIDISPONGIA-COERULEA, Tetrahedron, 50(16), 1994, pp. 4829-4834
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
50
Issue
16
Year of publication
1994
Pages
4829 - 4834
Database
ISI
SICI code
0040-4020(1994)50:16<4829:RAR2NP>2.0.ZU;2-V
Abstract
Two new 26-membered macrolides, reidispongiolide A (1) and B (2), have been isolated from the New Caledonian marine sponge Reidispongia coer ulea n.gen.n.sp. Levi and Levi and their structures elucidated. They a re related to sphinxolides previously isolate;l from an unknown nudibr anch and later from the sponge Neosiphonia superstes. 1 and 2 co-occur r with sphinxolide B (4) and D (3). These macrolides exhibited potent cytotoxicity against various human carcinoma cells.