SYNTHESIS AND ANTICARCINOGENIC ACTIVITY OF 5-FLUOROURACIL-1-ACETIC ACID COMPLEXES WITH RARE-EARTHS

Thirteen new solid complexes of 5-fluorouracilacetic acid (FAA) with r are earth metals (RE) have been synthesized. Elemental analysis, IR, U V spectra, TG-DTA, conductance measurements and H-1 NMR spectra have b een used to characterise them. The general formula of the complexes is Ln (FAA)3.2H2O (Ln = La --> Yb, Pm not included). The anticarcinogeni c activity of La(FAA)3.2H2O was tested. The results obtained showed th at the survival period of mice which had been transplanted with ascite s carcinoma (HepA) and then treated with the La complex can be prolong ed to 235% of the control but the ligand alone showed little anticarci nogenic activity. Some 42% of EC cancer cell growth can be inhibited b y the La complex. The LD50 is 500 mg kg-1.