SCREENING OF SINGLE DOSES OF NITRATES, CA LCIUM-ANTAGONISTS, BETA-ADRENOBLOCKERS AND RELEVANT COMBINATIONS IN PATIENTS WITH ANGINA-PECTORISOF EFFORT USING PAIRED BICYCLE ERGOMETRY TECHNIQUE

Fifteen males with stable angina pectoris were screened for efficacy o f antianginal drugs in single doses (isosorbide dinitrate, 10 mg; nife dipine, 20 mg; propranolol, 40 mg) and in combinations (ID+Pr, ID+Nf, Nf+Pr, Nf+Pr+ID). The findings at paired bicycle ergometries indicated that ID was most beneficial in monotherapy. Only two combinations (Nf +Pr and Nf+Pr+ID) were superior when compared to single drugs. Combina tions ID+Pr and ID+Nf had the same efficacy as ID. Interaction of the drugs assessed with two-dimensional variance analysis was insignifican t in all the combinations. Nf+Pr+ID combination had no advantages over two-drug combinations and induced worse tolerance.