C. Botel et T. Brinker, MEASUREMENT OF THE DYNAMICS OF THE CEREBROSPINAL-FLUID SYSTEM IN THE RAT, Journal of experimental animal science, 36(2-3), 1994, pp. 78-83
A technique for intracranial pressure (ICP) monitoring in the rat that
enables the measurement of the cerebrospinal outflow resistance (R(CS
F)) and the intracranial pressure-volume index (PVI) is described. A p
ermanent catheter placed into the cisterna magna through the occipital
bone was used. ICP, R(CSF) and PVI were measured in ten LEW rats. The
baseline ICP was 8 +/- 1.7 mm Hg (Mean +/- S.D.). The PVI was 0.0518
+/- 0.018 ml. The R(CSF) was 464 +/- 196 mm Hg ml(-1) min(-1) which is
less than reported previously. The cannulation technique is easy and
gives reliable pressure tracings. It enables ICP monitoring and estima
tion of the dynamics of the cerebrospinal fluid (CSF) system during ex
perimental surgical procedures in the rat.