FLORID BASAL-CELL HYPERPLASIA OF THE PROSTATE

Florid basal cell hyperplasia of the prostate is an uncommon prolifera tive condition, most often associated with adenomatous hyperplasia. It is considered a benign lesion although confusion with prostatic cance r is possible when one is not familiar with the histopathological appe arance. We report another two cases of the glandular type of basal cel l hyperplasia with immunohistochemical findings. Both lesions were com posed of crowded and rather small glands with piling up of basaloid ce lls. They showed immunohistochemical positivity for high molecular wei ght cytokeratin 34 beta E12, confirming their relationship with basal cells. We detected focal positivity of these basal cells for alpha-smo oth muscle actin, suggesting myoepithelial differentiation. Paucity of actin-positive smooth muscle cells in the stroma was noticed. One of the lesions showed some mild cytological atypia with prominent nucleol i and increased mitotic activity.