DIRECT SYNTHESIS OF AMIDES FROM CARBOXYLIC-ACIDS AND AMINES WITH PHENYLDICHLOROPHOSPHITE AS REAGENT IN AQUEOUS-MEDIUM

Amides with aliphatic and aromatic structure have been prepared by a d irect condensation reaction between carboxylic acids and amines in aqu eous medium, using phenyldichlorophosphite as reagent. The realisation of this reaction in the presence of water is a prove that diacylpheny lphosphites, which result in situ as intermediary products (leaving gr oups), have a relative stability to hydrolysis and react with amines, affording amides in moderate yields (31-54%). This reaction has a biol ogical importance, because the realisation of amide bond in biological syntheses of proteines, polypeptides etc. occurs also in aqueous medi um. The yields of this reaction increase at 30-40-degrees and decrease at 90-100-degrees, because in this last case the hydrolytic reactions become preponderent in comparison with the condensation reactions.