INTESTINAL UPTAKE OF TC-99M MDP IN A PATIENT WITH VIPOMA SYNDROME

Vipoma syndrome, or the diarrheogenic syndrome, is often caused by a p ancreatic islet cell tumor or a retroperitoneal neural tumor and is ma inly characterized by watery diarrhea, hypokalemia, and achlorhydria. Vasoactive intestinal polypeptide (VIP) Is generally the mediator in m ost cases. Intestinal uptake of Tc-99m MDP in a 32-year-old man with V ipoma syndrome is reported. He had normal calcium and phosphate levels . Multiple intestinal biopsies revealed no metastatic calcifications, necrosis, or amyloidosis, but only diffuse intestinal edema and an 80- centimeter-long ischemic segment in the ileum. A synthetic somatostati n analog that was administered to the patient can also be the reason f or the intestinal concentration of Tc-99m MDP in this case. To our kno wledge, intestinal accumulation of a bone agent in the Vipoma syndrome has not been described.