Indigenous food fermentations are one of the oldest forms of biotechno
logy, although the potential of the associated microorganisms has prob
ably not yet been fully realised. Many food fermentative microorganism
s are highly domesticated, although few studies have attempted to asse
ss the extent of the genetic resource which is available, or which str
ains should be preserved for the future. Many bacterial and fungal fer
mented foods are based on the utilization of solid substrates. Fundame
ntal studies on these model sytems could provide the necessary informa
tion to enable a more efficient exploitation of solid substrates in mo
dern biotechnology. Oppurtunities exist for the use of traditional fer
mentative microorganisms in biotechnology, either directly or followin
g genetic manipulation using conventional or molecular techniques. Exa
mples are presented to show the use of food fermentative and related m
icroorganisms for the production of food colours, flavours, enzymes, a
ntimicrobials and health products. Chitosan, a polymer present in the
hyphae of food fermentative fungi has applications in the food, pharma
ceutical and agricultural industries.