PARTICULAR SENSITIVITY OF THE MAMMALIAN HEART SINUS NODE CELLS

Authors
PETITJACQUES J BESCOND J BOIS P LENFANT J
Citation
J. Petitjacques et al., PARTICULAR SENSITIVITY OF THE MAMMALIAN HEART SINUS NODE CELLS, News in physiological sciences, 9, 1994, pp. 77-79
Citations number
15
Categorie Soggetti
Physiology
Journal title
News in physiological sciences → ACNP
ISSN journal
08861714
Volume
9
Year of publication
1994
Pages
77 - 79
Database
ISI
SICI code
0886-1714(1994)9:<77:PSOTMH>2.0.ZU;2-Q
Abstract
High resting adenylate cyclase activity, implying a high basal adenosi ne 3',5'-cyclic monophosphate level, seems to be a distinctive propert y of sinoatrial node cells of mammalian heart. This may explain why ac etylcholine depresses two ionic mechanisms involved in spontaneous act ivity of nodal myocytes, via inhibition of adenylate cyclase activity, without previous beta-adrenergic stimulation.