DECREASED CEREBRAL 5-HT1A RECEPTORS DURING AGING - REVERSAL BY GINKGO-BILOBA EXTRACT (EGB-761)

Citation
F. Huguet et al., DECREASED CEREBRAL 5-HT1A RECEPTORS DURING AGING - REVERSAL BY GINKGO-BILOBA EXTRACT (EGB-761), Journal of Pharmacy and Pharmacology, 46(4), 1994, pp. 316-318
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
00223573
Volume
46
Issue
4
Year of publication
1994
Pages
316 - 318
Database
ISI
SICI code
0022-3573(1994)46:4<316:DC5RDA>2.0.ZU;2-H
Abstract
Investigation of H-38-hydroxy-2(di-n-propylamino)tetralin binding to 5-HT1A receptors in cerebral cortex membranes of Wistar rats showed t hat the maximal number of binding sites (B-max) was reduced significan tly (22%) in aged (24-month-old) as compared with young (4-month-old) animals. Chronic treatment with Ginkgo biloba extract did not alter bi nding in young rats but increased binding density significantly (33%) in aged rats. These results confirm previously described age-related 5 -hydroxytryptaminergic alterations. Together with data in the literatu re, they also suggest a restorative effect in aged rats, associated wi th decreased receptor density resulting from the protective action of Ginkgo biloba extract treatment on neuronal membrane.