MOLECULAR-CLONING OF A CDNA-ENCODING A NOVEL FATTY-ACID-BINDING PROTEIN FROM RAT SKIN

Authors
WATANABE R FUJII H ODANI S SAKAKIBARA J YAMAMOTO A ITO M ONO T
Citation
R. Watanabe et al., MOLECULAR-CLONING OF A CDNA-ENCODING A NOVEL FATTY-ACID-BINDING PROTEIN FROM RAT SKIN, Biochemical and biophysical research communications, 200(1), 1994, pp. 253-259
Citations number
14
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
200
Issue
1
Year of publication
1994
Pages
253 - 259
Database
ISI
SICI code
0006-291X(1994)200:1<253:MOACAN>2.0.ZU;2-H
Abstract
A novel skin-type fatty acid-binding protein, termed cutaneous(C)-FABP , has been purified from rat skin and a cDNA clone for this protein ha s been identified. The purified protein had the ability to bind long c hain fatty acids like other rat FABPs. The deduced amino acid sequence of the cDNA clone comprises residues yielding a molecular mass for th e polypeptide of 15.1 kDa and exhibits around 50% identity to myelin P 2 protein, adipocyte FABP and heart FABP. Our results propose that C-F ABP is a new member of the FABP family. (C) 1994 Academic Press, Inc.