AN UNUSUAL EPITHELIAL PLEOMORPHIC GIANT-CELL TUMOR OF THE PANCREAS WITH OSTEOCLAST-TYPE CELLS

A case of giant cell tumour of the pancreas with a mixture of pleomorp hic giant cells and osteoclast-like cells is described. This associati on is rare and its histogenesis has been debated. The presence of a sm all differentiated adenocarcinomatous area at the periphery of the tum our indicates an epithelial origin. Moreover, some pleomorphic cells w ere positive for keratin (KL1). The osteoclast-like cells strongly exp ressed CD68 (a marker of histiomonocytic lineage) and did not show pro liferative activity. They probably correspond to an unusual reaction o f the stroma. Their clinical importance in this type of tumour remains unknown.