Most informative, practicable clinical, morphological and histomorphol
ogical criteria have been identified characterizing the stage of clini
cal evolution of chronic myeloid leukemia (CML) by the time of its dia
gnosis. Such criteria can be utilized for featuring the risk of short-
and long-term CML aggravation. The patients at risk of the disease ac
celeration are recognized, the survival for various risk groups is ana
lyzed. By a complex of significant signs the patients may be diagnosti
cally classified as being at standard, moderate and high risk.