CYTOLOGICAL AND BIOCHEMICAL ASPECTS OF IN VESTIGATION OF CEREBROSPINAL-FLUID IN THE PATIENTS WITH CHRONIC MYELOID-LEUKEMIA

The investigation of cell composition and different biochemical parame ters (ceruloplasmin, lactate dehydrogenase, aldolase, ferritin, beta-2 -microglobulin) in cerebrospinal fluid has been performed in 37 patien ts with chronic myeloid leukemia at different clinicohematological sta ges. The age of the patients ranged from 16 to 67 years. CNS involveme nt has been diagnosed in 8 (21.6 %) patients by clinical and cytologic al criteria and in 5 (13.5 %) patients on the basis of changes in liqu or cytograms and in biochemistry. Morphological substrate of leukemic infiltration may be represented by blast cells and cells of granulocyt ic line of all stages of differentiation. Direct correlation has been established between ferritin and beta-2-microglobulin levels in liquor and its cytological patterns. This permits a conclusion on possible u sage of liquor concentration of beta-2-microglobulin and ferritin meas urements as additional tests in the diagnosis of neuroleukemia in chro nic myeloid leukemia.