Structural hemoglobinopathy due to carriage of Hb Camden was diagnosed
in a male patient and his mother. Anomalous Hb was detected after a d
etailed analysis of the clinical evidence, blood smears microscopy, ma
rrow examination, data obtained by a complex of methods to identify un
stable Hb. It was defined as Hb Camden beta 131 GLN-->GLU. The carriag
e of this variant brings no clinical manifestations, but leads to impa
ired red cells morphology, decline of their life span, enhanced hemoly
sis. These properties are typical for mutant Hb lacking stability. Hb
Camden carriage is considered as a compensatory hemolytic process.