MORPHOFUNCTIONAL CHARACTERISTICS OF BONE- MARROW ERYTHROID-CELLS IN SOME VARIANTS OF MYELODYSPLASIA SYNDROME

Refractory anemia (RA) and RA with blast excess (RABE) showed inhibite d proliferation of bone marrow erythroid cells (EC), the lowest values being in RABE. The latter, however, was accompanied with the highest count of PAS-positive EC, uneffective erythropoiesis being present in both RA and RABE. In sideroblast anemia the above proliferation was al so inhibited, but uneffective erythropoiesis played much more pronounc ed role in pathogenesis of this anemia than in RA and RABE. The percen tage of PAS-positive EC averaged 39.0 %. The findings contribute to mo re profound understanding of anemia arising in myelodysplasia syndrome , to more accurate evaluation of therapeutic effect and prognosis in t he above disease.