Tg. Sarycheva et al., MORPHOFUNCTIONAL CHARACTERISTICS OF BONE- MARROW ERYTHROID-CELLS IN SOME VARIANTS OF MYELODYSPLASIA SYNDROME, Terapevticeskij arhiv, 65(7), 1993, pp. 52-54
Refractory anemia (RA) and RA with blast excess (RABE) showed inhibite
d proliferation of bone marrow erythroid cells (EC), the lowest values
being in RABE. The latter, however, was accompanied with the highest
count of PAS-positive EC, uneffective erythropoiesis being present in
both RA and RABE. In sideroblast anemia the above proliferation was al
so inhibited, but uneffective erythropoiesis played much more pronounc
ed role in pathogenesis of this anemia than in RA and RABE. The percen
tage of PAS-positive EC averaged 39.0 %. The findings contribute to mo
re profound understanding of anemia arising in myelodysplasia syndrome
, to more accurate evaluation of therapeutic effect and prognosis in t
he above disease.