STRIKING DIVERSITY OF DR15 HAPLOTYPES IN CROATIANS

Citation
Z. Grubic et al., STRIKING DIVERSITY OF DR15 HAPLOTYPES IN CROATIANS, Tissue antigens, 49(2), 1997, pp. 180-182
Citations number
19
Categorie Soggetti
Immunology,"Cell Biology
Journal title
ISSN journal
00012815
Volume
49
Issue
2
Year of publication
1997
Pages
180 - 182
Database
ISI
SICI code
0001-2815(1997)49:2<180:SDODHI>2.0.ZU;2-T
Abstract
Analysis of HLA class II polymorphism revealed DR2 as the most frequen t antigen in Croatians (20, 9%). The observed DR2 subtypes and their f requencies were as follows: DRB1160l - 9.9%; 1501 - 8.5%; 1602 - 1.8% , 1502 - 1.4% and 1503 - 0.7%. Furthermore, analysis of probable DRB1- DQA1-DQB1 haplotype associations in unrelated individuals revealed a h igh diversity of DR15 haplotype associations. Now, to confirm this obs ervation from unrelated individuals, family studies have been performe d. Sixty-eight families, with at least one parent and one offspring DR 2 positive, have been studied. DRB11601-DQA1*0102-DQB1*0502 seems to be conserved haplotype in Croatians while DRB115 haplotypes showed ex tremely high diversity. Seven rare DR15 haplotypes are observed; six o f these appear twice and one only once. Two haplotypes appear to be un ique to Croatians: DRB11501-DQA1*0102-DQB1*0501 and DRB1*1501-DQA1*01 02-DQB10604. This confirmation of extremely high diversity of DR15 ha plotypes in Croatians is a valuable tool for unrelated bone marrow tra nsplantation and DR2 disease association studies.