AN ACHIRAL (OLIGO)NUCLEOTIDE ANALOG

Authors
VANVLIET MJ VISSCHER J SCHWARTZ AW
Citation
Mj. Vanvliet et al., AN ACHIRAL (OLIGO)NUCLEOTIDE ANALOG, Journal of molecular evolution, 38(5), 1994, pp. 438-442
Citations number
17
Categorie Soggetti
Genetics & Heredity",Biology
Journal title
Journal of molecular evolution → ACNP
ISSN journal
00222844
Volume
38
Issue
5
Year of publication
1994
Pages
438 - 442
Database
ISI
SICI code
0022-2844(1994)38:5<438:AA(A>2.0.ZU;2-E
Abstract
An achiral nucleotide analog based on barbituric acid has been synthes ized. The analog, which is 5,5-di(2-phosphoethyl)barbituric acid, unde rgoes extensive oligomerization in aqueous solution, when activated, t o produce pyrophosphate-linked chains. In contrast to a number of othe r bisphosphorylated nucleoside analogs which have been studied, the co mpound has little tendency to cyclize. The possible prebiotic implicat ions are discussed.