SYNTHESIS OF TRIPLE-HELIX FORMING OLIGONUCLEOTIDES WITH A STRETCHED PHOSPHODIESTER BACKBONE

Authors
RAO TS JAYARAMAN K DURLAND RH REVANKAR GR
Citation
Ts. Rao et al., SYNTHESIS OF TRIPLE-HELIX FORMING OLIGONUCLEOTIDES WITH A STRETCHED PHOSPHODIESTER BACKBONE, Nucleosides & nucleotides, 13(1-3), 1994, pp. 255-273
Citations number
34
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
13
Issue
1-3
Year of publication
1994
Pages
255 - 273
Database
ISI
SICI code
0732-8311(1994)13:1-3<255:SOTFOW>2.0.ZU;2-2
Abstract
Total synthesis of novel DMT-phosphoramidites of thymidine (11 and 15) and 2'-deoxyguanosine (8 and 20) have been accomplished. The utility of these modified building blocks in the preparation of triple helix f orming oligodeoxyribonucleotides with a stretched phosphodiester backb one has been evaluated. It was found that the oligonucleotides with ex tended backbones were unable to enhance the binding to duplex targets containing CG or TA base pairs.