SYNTHESIS AND ANTIVIRAL ACTIVITY OF SOME FLUORINATED NUCLEOTIDE DERIVATIVES

Authors
DYATKINA N ARZUMANOV A KRAYEVSKY A OHARA B GLUZMAN Y BARON P MACLOW C POLSKY B
Citation
N. Dyatkina et al., SYNTHESIS AND ANTIVIRAL ACTIVITY OF SOME FLUORINATED NUCLEOTIDE DERIVATIVES, Nucleosides & nucleotides, 13(1-3), 1994, pp. 325-337
Citations number
23
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
13
Issue
1-3
Year of publication
1994
Pages
325 - 337
Database
ISI
SICI code
0732-8311(1994)13:1-3<325:SAAAOS>2.0.ZU;2-O
Abstract
A number of 3'-fluoro-3'-deoxythymidine 5'-phosphonates and nucleoside 5'-phosphorofluoridates were prepared to study their ability to inhib it replication of HIV-1. Compounds, the 5'-phosphorofluoridates of 3'- azido-3'-deoxythymidine (VIIIc), 3'-fluoro-3'-deoxythymidine (VIIId) a nd 3'-deoxy-2',3'-didehydrothymidine (VIIIe), exhibit potent anti-HTV- 1 activities.