NUCLEIC-ACID RELATED-COMPOUNDS .82. CONVERSIONS OF ADENOSINE TO INOSINE 5-BETA-THIOETHER DERIVATIVES WITH ASPERGILLUS-ORYZAE ADENOSINE-DEAMINASE OR ALKYL NITRATES - SUBSTRATE AND INHIBITORY ACTIVITIES OF INOSINE 5'-THIOETHER DERIVATIVES WITH PURINE NUCLEOSIDE PHOSPHORYLASE

Adenosine derivatives lacking a 5'-hydroxyl group seldom act as altern ative substrates of adenosine deaminases from calf intestine and other mammalian sources. A deaminase from Aspergillus oryzae deaminated ade nosine 5'-thioether derivatives cleanly and more efficiently than alky l nitrites. The inosine derivatives were very poor alternative substra tes and weak inhibitors of purine nucleoside phosphorylase.