SYNTHESIS OF ACYCLONUCLEOSIDE PHOSPHONATES AS ANTIVIRAL AGENTS AGAINST CYTOMEGALOVIRUS

Authors
REIST EJ BRADFORD WW HUFFMAN J SIDWELL RW RUHLANDFRITSCH BL STURM PA ZAVERI NT
Citation
Ej. Reist et al., SYNTHESIS OF ACYCLONUCLEOSIDE PHOSPHONATES AS ANTIVIRAL AGENTS AGAINST CYTOMEGALOVIRUS, Nucleosides & nucleotides, 13(1-3), 1994, pp. 539-550
Citations number
17
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
13
Issue
1-3
Year of publication
1994
Pages
539 - 550
Database
ISI
SICI code
0732-8311(1994)13:1-3<539:SOAPAA>2.0.ZU;2-X
Abstract
Phosphonic acid analogs of ACV and DHPG that are isosteric with ACV ph osphate and DHPG phosphate have been synthesized and evaluated for ant iviral activity against human, murine. and guinea pig strains of cytom egalovirus. The phosphonates showed high activity against all of the s trains. They were also evaluated against a DHPG resistant strain of hu man cytomegalovirus. Although the activity dropped considerably, signi ficant antiviral activity was still evident.