GUANOSINE DERIVATIVES AS IMMUNOSTIMULANTS - DISCOVERY OF LOXORIBINE

Authors
CHEN R GOODMAN MG ARGENTIERI D BELL SC BURR LE COME J GOODMAN JH KLAUBERT DH MARYANOFF BE POPE BL RAMPULLA MS SCHOTT MR REITZ AB
Citation
R. Chen et al., GUANOSINE DERIVATIVES AS IMMUNOSTIMULANTS - DISCOVERY OF LOXORIBINE, Nucleosides & nucleotides, 13(1-3), 1994, pp. 551-562
Citations number
30
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
13
Issue
1-3
Year of publication
1994
Pages
551 - 562
Database
ISI
SICI code
0732-8311(1994)13:1-3<551:GDAI-D>2.0.ZU;2-T
Abstract
7-Allyl-8-oxoguanosine (loxoribine, 5) was selected from a series of g uanosine derivatives for further evaluation as an immunostimulant. Num erous related analogs were also synthesized and evaluated: 2',3'-ketal s of 5 are particularly interesting because they are active, apparentl y without being cleaved to the free nucleoside.