A CONVENIENT ROUTE TO 2'-ALLENYL NUCLEOSIDES

Authors
JARVI ET MCCARTHY JR
Citation
Et. Jarvi et Jr. Mccarthy, A CONVENIENT ROUTE TO 2'-ALLENYL NUCLEOSIDES, Nucleosides & nucleotides, 13(1-3), 1994, pp. 585-598
Citations number
23
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
13
Issue
1-3
Year of publication
1994
Pages
585 - 598
Database
ISI
SICI code
0732-8311(1994)13:1-3<585:ACRT2N>2.0.ZU;2-G
Abstract
The first synthesis of allenic nucleosides derived from natural ribonu cleosides is reported. 2'-Deoxy-2'-(ethenylidene)cytidine (8) and 2'-d eoxy-2'-(ethenylidine)adenosine (21) were prepared by a modification o f the method developed by Tsuji and co-workers for the synthesis of al lenes. The biological rationale for the synthesis of these compounds i s discussed.