NUCLEOSIDE ANALOGS ON THE BASIS OF 4(R),5(R)-DIHYDROXYMETHYL-2-METHYL-1,3-DIOXOLANE

New nucleoside analogues on the basis of 4(R),S(R)-dihydroxymethyl-2-m ethyl-1, 3-dioxolane have been prepared Alkylation of thymine, adenine and N-2-palmitoyl- guanine with 2-bromomethyl-4(R), 5(R)-dibenzyloxym ethyl-1, 3-dioxolane followed by separation of regio isomers by adsorp tion chromatography and deprotection yielded the desired chiral nucleo side analogues. The structures of thus prepared compounds were confirm ed by UV and PMR spectroscopy. The obtained compounds 11 have no anti- HIV and antiherpetic activity and are not cytotoxic.