ANTINEOPLASTIC AND ANTIVIRAL ACTIVITIES OF PODOPHYLLOTOXIN RELATED LIGNANS

28 cyclolignans, most of them derived from podophyllotoxin, have been evaluated for their antineoplastic and antiviral activities. They were subjected to screening against P-388 murine leukemia, A-549 human lun g carcinoma, and HT-29 colon carcinoma, while antiviral assays were pe rformed on herpes simplex virus type I infecting fibroblasts of monkey kidney (HSV/CV-1) and on vesicular stomatitis virus infecting fibrobl asts of hamster kidney (VSV/BHK). A number of substances were active i n both groups of assays at concentrations below 1 mu M; deoxypodophyll otoxin (1) being the most potent compound in all cases.