STUDY OF THE MECHANISMS INVOLVED IN HYDROXOCOBALAMIN INTERFERENCE WITH DETERMINATION OF SOME BIOCHEMICAL PARAMETERS

Authors
GOURLAIN H CALIEZ C LAFORGE M BUNEAUX F LEVILLAIN P
Citation
H. Gourlain et al., STUDY OF THE MECHANISMS INVOLVED IN HYDROXOCOBALAMIN INTERFERENCE WITH DETERMINATION OF SOME BIOCHEMICAL PARAMETERS, Annales de biologie clinique, 52(2), 1994, pp. 121-124
Citations number
11
Categorie Soggetti
Medicine, Research & Experimental",Biology
Journal title
Annales de biologie clinique → ACNP
ISSN journal
00033898
Volume
52
Issue
2
Year of publication
1994
Pages
121 - 124
Database
ISI
SICI code
0003-3898(1994)52:2<121:SOTMII>2.0.ZU;2-V
Abstract
Hydroxocobalamin (OHCo), a red pigment used as an antidote in cyanide poisoning, interferes with determination of some biochemical parameter s. Plasma pools were spiked with two concentrations of OHCo and eight parameters (CK, SGOT, SGPT, ALP, lactic acid, creatinine, glucose, bil irubin) were assayed using Dimension and Aca m automated analyzers (Du Pont Instruments), Two parameters were affected by the presence of OH Co: CK and bilirubin. This study documents the type of interferences, spectral or chemical, and its probable causes.