Df. Schaling et al., POSSIBILITIES AND LIMITATIONS OF RADIOIMMUNOSCINTIGRAPHY AND CONVENTIONAL DIAGNOSTIC MODALITIES IN CHOROIDAL MELANOMA, British journal of ophthalmology, 78(4), 1994, pp. 244-248
A prospective clinical study to assess the value of immunoscintigraphy
with a monoclonal antibody (MoAb) against high molecular weight melan
oma associated antigen (225.28S) was performed in 43 patients with cho
roidal melanoma; in six patients with a lesion suspected of being chor
oidal melanoma, and in seven patients with a benign lesion simulating
a choroidal melanoma. The results of immunoscintigraphy in choroidal m
elanoma were compared with results of conventional diagnostic modaliti
es like ultrasonography and fluorescein angiography. Planar scintigrap
hy showed a detection rate of 49% which is comparable with other studi
es. The detection with scintigraphy was correlated to the size of the
choroidal melanoma. The use of single photon computed tomography did n
ot increase the sensitivity of immunoscintigraphy. Ultrasonography yie
lded a correct diagnosis in 37 of 42 melanomas (88%). With fluorescein
angiography a correct diagnosis was obtained in 11 of 30 melanomas (3
6.6%). The value of immunoscintigraphy with MoAb 225.28S in small chor
oidal melanomas is limited; its reliability increases in large tumours
. Immunohistochemistry with MoAb 225.28S showed antigen expression in
95% of the stained tissue specimens of choroidal melanoma.