ACTION OF PLASTICIZERS ON SODIUM CARBOXYMETHYLCELLULOSE AS A COATING POLYMER FOR SPRAY-DRIED PRODUCTS

Spray-dried products using sodium carboxymethylcellulose as the coatin g polymer were prepared. The effects of plasticizers which could be co nsidered as belonging to two groups, polyols and carboxylic acids, wer e studied. The findings showed that the dissolution T-50% values for s pray-dried products with glycerin, polyethylene glycol 6000 and propyl ene glycol were generally the same as that without any plasticizer, wh ereas that with triethylcitrate was faster. As for carboxylic acids, s pray-dried products with succinic acid showed the slowest drug release in comparison with the other plasticizers, the fastest being those wi th oxalic and tartaric acids, whilst intermediate were products with g lutaric and phthalic acids. Cast films containing the same constituent s as the feed spray provided a fairly good indication of the spray-dri ed products to be formed.