IMPROVEMENT IN THE DISSOLUTION PROPERTIES OF THEOPHYLLINE WITH BETA-CYCLODEXTRIN

An improvement in the dissolution of theophylline with beta-cyclodextr in was achieved by subjecting them to co-grinding and freeze-drying me thods. The products obtained were examined by the phase solubility met hod, differential scanning calorimetry and X-ray diffractometry. The p roducts thus prepared were evaluated with respect to their dissolution behaviour and particle sizes, and compared with the pure drug and the physical mixture of theophylline and beta-cyclodextrin. The improveme nt in the dissolution profile of theophylline in the interacted form m ay be due to its amorphous state, to increased wettability, or to the formation of an inclusion complex.