TYROSOL AS AUTOREGULATORY FACTOR D(1) IN THE YEAST SACCHAROMYCES-CEREVISIAE

Autoregulatory factor d(1), which induces transformation of vegetative cells into refractile resting forms, has been isolated from culture m edium of the yeast Saccharomyces cerevisiae. This bioregulator was ide ntified as 2-(4-hydroxyphenyl)ethane-1-ol (tyrosol). At a concentratio n of 5 - 15 mu M it stimulated endogenous respiration of producer cell s at 20 - 80 mu M respiration was inhibited, and at 200 - 800 mu M tra nsformation of vegetative cells into resting forms was induced. The ef fect of tyrosol was non-specific: at a concentration of 64 - 86 mu M i t inhibited respiration in cells of Escherichia coli and Bacillus cere us.