The term dry eye refers to an ocular surface condition caused by a gro
up of diseases sharing the common signs and symptoms of dryness. Dry e
ye syndrome and keratoconjunctivitis sicca are often used interchangea
bly; however, they are actually separate conditions that lie along a d
isease spectrum that affects the wetting and lubricating properties of
tears. Topics discussed in this article include tear film, etiology o
f dry eye syndrome, systemic diseases, and the clinical picture.