GABA(A) RECEPTORS ON RAT CEREBELLAR GRANULE CELLS ARE POTENTLY ACTIVATED BY MUSCIMOL BUT ONLY SLIGHTLY MODULATED BY THE BENZODIAZEPINE AGONIST FLUNITRAZEPAM

Authors
BALDELLI P CUPELLO A ROBELLO M
Citation
P. Baldelli et al., GABA(A) RECEPTORS ON RAT CEREBELLAR GRANULE CELLS ARE POTENTLY ACTIVATED BY MUSCIMOL BUT ONLY SLIGHTLY MODULATED BY THE BENZODIAZEPINE AGONIST FLUNITRAZEPAM, Amino acids, 6(2), 1994, pp. 155-163
Citations number
15
Categorie Soggetti
Biology
Journal title
Amino acids → ACNP
ISSN journal
09394451
Volume
6
Issue
2
Year of publication
1994
Pages
155 - 163
Database
ISI
SICI code
0939-4451(1994)6:2<155:GRORCG>2.0.ZU;2-F
Abstract
GABA(A) receptors present on rat cerebellar granule cells in culture w ere studied by the whole cell patch clamp technique. Muscimol appeared to be more potent than GABA itself in activating C1(-) currents. A be nzodiazepine, flunitrazepam, only slightly (10%) potentiated the GABA action. These results support the previous suggestion that GABA(A) rec eptors containing the delta subunit, such as those in the cerebellum g ranule cells, are potently activated by muscimol. The present results also bear out the concept that GABA action on receptors containing the delta subunit is not potentiated by benzodiazepines.