TESTOSTERONE MODULATES MESOLIMBIC DOPAMINERGIC ACTIVITY IN MALE-RATS

Authors
HERNANDEZ L GONZALEZ L MURZI E PAEZ X GOTTBERG E BAPTISTA T
Citation
L. Hernandez et al., TESTOSTERONE MODULATES MESOLIMBIC DOPAMINERGIC ACTIVITY IN MALE-RATS, Neuroscience letters, 171(1-2), 1994, pp. 172-174
Citations number
18
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
171
Issue
1-2
Year of publication
1994
Pages
172 - 174
Database
ISI
SICI code
0304-3940(1994)171:1-2<172:TMMDAI>2.0.ZU;2-C
Abstract
Male rats were castrated before puberty. When they were adult, the act ivity of their mesolimbic dopamine system was tested by ventral striat um microdialysis. Amphetamine injections increased dopamine more in ca strated rats than in normal rats. This exaggerated response was attenu ated by testosterone replacement therapy. The mechanism by which andro gens modulate the activity of the mesolimbic dopamine system is discus sed.