A HYPOTENSIVE EFFECT OF RETARDED DILTIAZE M (DILREN) AND ITS ACTION ON CENTRAL HEMODYNAMICS IN HYPERTENSIVE PATIENTS

Calcium antagonist dilren in a short course was given to 11 hypertensi ve subjects (AH stage II). A clinical response in the majority of the patients was associated with a decline in systolic, mean arterial and resting diastolic pressure (by 8.1, 7.8 and 11.5 %, respectively). In orthostasis and under isometric loading dynamic values of arterial pre ssure tended to lowering, especially diastolic (by 6.7 and 8.3 %, resp ectively);. Reduced pressure resulted from a significant reduction in the total peripheral resistance (by 19.8 % at rest, in orthostasis by 10 %, in isometric load by 26.1 %). Minute blood volume increased beca use of a rise in stroke output. Dilren is recommended in a standard do se 300 mg/day in mild hypertension and in an individual dose 600 mg/da y in moderate disease.