A common problem in medical diagnosis is to combine information from s
everal tests or patient characteristics into a decision rule to distin
guish diseased from healthy patients. Among the statistical procedures
proposed to solve this problem, recursive partitioning is appealing f
or the easily-used and intuitive nature of the rules it produces. The
rules have the form of classification trees, in which each node of the
tree represents a simple question about one of the predictor variable
s, and the branch taken depends on the answer. The authors consider th
e role of misclassification costs in developing classification trees.
By varying the ratio of costs assigned to false negatives and false po
sitives, a series of classification trees are generated, each optimal
for some range of cost ratios, and each with a different sensitivity a
nd specificity. The set of sensitivity-specificity combinations define
a curve that can be used like an ROC curve.