CENTRAL ACTIVITY OF PEPTIDE GLY-PRO-HYP - THE MAIN COMPONENT OF COLLAGEN DEGRADATION PRODUCTS MIXTURE

The effect of tripeptide Gly-Pro-Hyp on the central nervous system was studied. The peptide Gly-Pro-Hyp is a main component of the mixture o f collagen type I degradation products obtained by 6-h digestion with bacterial collagenase. The investigated peptide in the doses 1 mu g, 2 mu g, and 5 mu g significantly reduces the psychomotor activity of an imals, intensifies haloperidol-induced catalepsy and enhances stereoty py behaviour after apomorphine administration. The central activity of Gly-Pro-Hyp is similar to the action of collagen degradation products mixture. This suggests that this peptide may be the active substance responsible for the effects of degradation products of collagen type I .