In 75-80% of all clinically significant prostate cancer, the periphera
l zone appears to be hypoechoic on transrectal ultrasound (TRUS). Howe
ver, examination by TRUS alone in a screening program is not recommend
ed due to its low sensitivity. The combination of prostate-specific an
tigen, digital rectal examination, and TRUS increases the detection ra
te of prostate cancer. In prostate cancer arising from the transition
zone, TRUS findings are often nonspecific. Even prostate biopsies migh
t be negative due to the location of this tumor. Anterior biopsies of
the transition zone will identify these prostate cancers. Color Dopple
r ultrasound of the prostate has little additional value over TRUS alo
ne in the diagnosis of prostate cancer.