THE SYNTHESIS OF SOME TRITIUM-LABELED TERMINATORS OF DNA-SYNTHESIS

2',3'-Dideoxythymidine, 2',3'-dideoxyadenosine, 2',3'dideoxycytidine-5 '-phosphonate, thymidine-5' -phosphonate, labelled with tritium in the carbohydrate residue; thymidine-5'-methylphosphonate labelled in the methyl of the phosphonate group and 2',3'-dideoxyadenosine labelled in the base and/or carbohydrate residue were prepared by hydrogenolysis with tritium gas. The reaction of solid state catalytic hydrogenation was studied and tritium-labelled azydothymidine, azydothymidine-5'-pho sphonate, acyclovire, acyclovire-5'-phosphonate were synthesized. A nu mber of general approaches to the synthesis of tritium-labelled termin ators of DNA synthesis were formulated.