Hh. Seltzman et al., METALLATION REDUCTION AS A NEW APPROACH TO TRITIUM LABELING - THE SYNTHESIS OF [H-3] IBOGAINE/, Journal of labelled compounds & radiopharmaceuticals, 34(4), 1994, pp. 367-375
A new method is presented for the tritiation of aryl compounds with tr
itium gas which is conducted on the underivatized substrate. Combined
directed ortho metallation and facile reduction of the carbon-potassiu
m bond affords incorporation of tritium at high specific activity unde
r mild conditions. The metallation/reduction method is demonstrated fo
r the preparation of H-3ibogaine.