METALLATION REDUCTION AS A NEW APPROACH TO TRITIUM LABELING - THE SYNTHESIS OF [H-3] IBOGAINE/

Authors
SELTZMAN HH ODEAR DF LAUDEMAN CP CARROLL FI WYRICK CD
Citation
Hh. Seltzman et al., METALLATION REDUCTION AS A NEW APPROACH TO TRITIUM LABELING - THE SYNTHESIS OF [H-3] IBOGAINE/, Journal of labelled compounds & radiopharmaceuticals, 34(4), 1994, pp. 367-375
Citations number
20
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
34
Issue
4
Year of publication
1994
Pages
367 - 375
Database
ISI
SICI code
0362-4803(1994)34:4<367:MRAANA>2.0.ZU;2-R
Abstract
A new method is presented for the tritiation of aryl compounds with tr itium gas which is conducted on the underivatized substrate. Combined directed ortho metallation and facile reduction of the carbon-potassiu m bond affords incorporation of tritium at high specific activity unde r mild conditions. The metallation/reduction method is demonstrated fo r the preparation of H-3ibogaine.