CONCISE SYNTHESIS OF A TAXOL A-RING SYNTHON - FORMATION OF A 1,2-ALKYLIDENE LINKAGE VIA ACETYLENE CHEMISTRY

Authors
CRICH D CRICH JZ
Citation
D. Crich et Jz. Crich, CONCISE SYNTHESIS OF A TAXOL A-RING SYNTHON - FORMATION OF A 1,2-ALKYLIDENE LINKAGE VIA ACETYLENE CHEMISTRY, Tetrahedron letters, 35(16), 1994, pp. 2469-2472
Citations number
56
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
16
Year of publication
1994
Pages
2469 - 2472
Database
ISI
SICI code
0040-4039(1994)35:16<2469:CSOATA>2.0.ZU;2-Y
Abstract
A taxol A ring-synthon is obtained by oxidative cyclization of homoger anic acid with mercuric triflate followed by oxidative demercuration; the Meyer-Schuster rearrangement is then employed to form the highly s terically hindered taxol 1,2-bond.